Artificial Intelligence in Medicine
Volume 40, Issue 1 , Pages 57-63 , May 2007

A stochastic model of susceptibility to antibiotic therapy—The effects of cross-resistance and treatment history

  • Alina Zalounina

      Affiliations

    • Center for Model-based Medical Decision Support, Niels Jernes Vej 14, Aalborg University, 9220 Aalborg East, Denmark
    • Corresponding Author InformationCorresponding author. Tel.: +45 9635 8795; fax: +45 9815 5816.
    • ,
  • Mical Paul

      Affiliations

    • Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah-Tiqva, Israel
    • ,
  • Leonard Leibovici

      Affiliations

    • Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah-Tiqva, Israel
    • ,
  • Steen Andreassen

      Affiliations

    • Center for Model-based Medical Decision Support, Niels Jernes Vej 14, Aalborg University, 9220 Aalborg East, Denmark

Received 13 March 2006 ,Revised 12 October 2006 ,Accepted 28 December 2006.

References 

  1. Andreassen S, Leibovici L, Paul M, Nielsen A, Zalounina A, Kristensen L, et al. A probabilistic network for fusion of data and knowledge in clinical microbiology. In:  Husmeier D,  Dybowski R,  Roberts S editor. Probabilistic modeling in bioinformatics and medical informatics. London: Springer; 2004;p. 451–472
  2. Leibovici L, Gitelman V, Yehezkeli Y, Poznanski O, Milo G, Paul M, et al. Improving first antibiotic treatment: prospective, non-intervention testing a decision support system. J Intern Med. 1997;242:395–400
  3. Shortliffe E. Computer-based medical consultations: MYCIN. New York: North-Holland; 1976;
  4. Dybowski R, Gransden W, Phillips I. Towards a statistically oriented decision support system for the management of septicaemia. Artif Intell Med. 1993;5:489–502
  5. Evans R, Pestotnik S, Classen D, Clemmer T, Weaver L, Orme J, et al. A computer-assisted management program for antibiotics and other antiinfective agents. New Engl J Med. 1998;338:232–238
  6. Lucas J, de Bruijn N, Schrink K, Hoepelman A. A probabilistic and decision-theoretic approach to the management of infectious disease at the ICU. Artif Intell Med. 2000;19:251–279
  7. The TREAT Working Group . Improving empirical antibiotic treatment using TREAT, a computerised decision support system: cluster randomised trial. J Antimicrob Chemother. 2006;58:1238–1245
  8. Hugin expert. HUGIN System Introduction, version 6.7. Hugin Expert A/S, Aalborg, Denmark. (http://www.hugin.dk); 2006 [accessed: 25 August 2006].
  9. Kristensen B. Construction and evaluation of a decision support system for first antibiotic treatment of bacteraemia. PhD thesis. Denmark: Aalborg University; 2003.
  10. Andreassen S, Riekehr C, Kristensen B, Schønheyder H, Leibovici L. Using probabilistic and decision-theoretic methods in treatment and prognosis modeling. Artif Intell Med. 1999;15:121–134
  11. von Neumann J, Morgenstern O. Theory of games and economic behavior. New York: Wiley; 1953;
  12. Paul M, Andreassen S, Nielsen A, Tacconelli E, Almanasreh N, Fraser A, et al. Prediction of bacteremia using TREAT, a computerized decision support system. Clin Infect Dis. 2006;42:1274–1282
  13. Leibovici L, Paul M, Kristensen B, Andreassen S. Significance of early trends in patients with bloodstream infections. In: Proceedings of the 43rd interscience conference on antimicrobial agents and chemotherapy (ICAAC), vol. L-118. Chicago, USA, September 2003. American Society for Microbiology; 2003;p. 404

PII: S0933-3657(07)00013-9

doi: 10.1016/j.artmed.2006.12.007

Artificial Intelligence in Medicine
Volume 40, Issue 1 , Pages 57-63 , May 2007

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